Projects with different levels of intervention are producing changes in the steel city of Pittsburgh and the iconic motor city of Detroit, two of America’s Rust-Belt cities. Architecture is determining new spatialities, uses and forms, mainly by engaging the remodeling of structural skeletons and architecture materials, found assets in a context marked by the post-industrial crisis. Through the narration of several case studies, it is possible to reflect on the current role played by projects and architects in redefining a different live, work and play production system.